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A Modified In vitro Invasion Assay to Determine the Potential Role of Hormones, Cytokines and/or Growth Factors in Mediating Cancer Cell Invasion
Published on: April 24, 2015
Possible correlation between tumor invasiveness and low serum cholesterol
M Shinitzky1, E Shaharabani, Y Skornick
1Department of Membrane Research, Weizmann Institute of Science, Rehovot, Israel.
Abstract:
The predisposition to solid tumor of individuals with low serum cholesterol may correlate with membrane properties of the emerging neoplastic cells. Evidence is presented to indicate that cholesterol content in the membrane of tumor cells is adjusted with respect to the serum cholesterol. Upon incorporation of cholesterol, tumor cells, which are exemplified here by colon and gastric carcinoma cells, become substantially more immunogenic and therefore more susceptible to clearance by the immune system.
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