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Updated: Nov 7, 2025
Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging
Published on: July 19, 2016
Chemiluminescent self-reported unfolding of single-chain nanoparticles
Fabian R Bloesser1, Sarah L Walden1, Ishrath M Irshadeen1
1School of Chemistry and Physics and Centre for Materials Science Queensland University of Technology (QUT), 2 George Street, Brisbane, QLD 4000, Australia. christopher.barnerkowollik@qut.edu.au.
Abstract:
We demonstrate the light-induced, crosslinker mediated collapse of linear polymer chains into single-chain nanoparticles (SCNPs) capable of self-reporting their unfolding. The crosslinker entails a phenyloxalate motif allowing for the targeted degradation of the SCNPs via addition of hydrogen peroxide that triggers chemiluminescence (CL). The time-dependant CL emission can serve as a guide to follow the time dependent unfolding of the SCNPs, allowing for a qualitative assessment of the underlying mechanism.
