Consanguineous marriage and rare bleeding disorders

Area of Science:

• Genetics
• Public Health
• Hematology

Background:

• Rare bleeding disorders (RBDs) are a diverse group of inherited conditions.
• Consanguineous marriage is prevalent in many communities, facilitating the inheritance of recessive genetic disorders.
• Challenges in diagnosis and treatment of RBDs are amplified in developing countries.

Purpose of the Study:

• To examine the link between consanguineous marriage and the incidence of rare bleeding disorders.
• To explore preventive measures for reducing the occurrence of RBDs.
• To discuss the prevalence and contributing factors of consanguineous marriage in the Middle East concerning RBDs.

Main Methods:

• A literature review was conducted using PubMed and Google Scholar in November 2020.
• Keywords included "rare bleeding disorders" and "consanguineous marriage."
• The review focused on prevalence, contributing factors, and prevention strategies.

Main Results:

• Consanguineous marriages are associated with a higher incidence of rare bleeding disorders.
• The Middle East shows a notable prevalence of consanguineous marriages, contributing to RBDs.
• Limited healthcare resources in developing nations exacerbate the clinical management of RBDs.

Conclusions:

• Consanguinity plays a significant role in the inheritance patterns of rare bleeding disorders.
• Healthcare systems should implement targeted prevention strategies, including genetic counseling for couples considering consanguineous marriage.
• Addressing socioeconomic and healthcare infrastructure limitations is vital for managing RBDs effectively.