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Consanguineous marriage and rare bleeding disorders
1Central Diagnostic Laboratories, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Insights
Consanguineous marriages increase the incidence of rare bleeding disorders (RBDs) by allowing recessive genes to persist. Prevention strategies and genetic counseling are crucial to minimize RBDs in affected populations.
Area of Science:
- Genetics
- Public Health
- Hematology
Background:
- Rare bleeding disorders (RBDs) are a diverse group of inherited conditions.
- Consanguineous marriage is prevalent in many communities, facilitating the inheritance of recessive genetic disorders.
- Challenges in diagnosis and treatment of RBDs are amplified in developing countries.
Purpose of the Study:
- To examine the link between consanguineous marriage and the incidence of rare bleeding disorders.
- To explore preventive measures for reducing the occurrence of RBDs.
- To discuss the prevalence and contributing factors of consanguineous marriage in the Middle East concerning RBDs.
Main Methods:
- A literature review was conducted using PubMed and Google Scholar in November 2020.
- Keywords included "rare bleeding disorders" and "consanguineous marriage."
- The review focused on prevalence, contributing factors, and prevention strategies.
Main Results:
- Consanguineous marriages are associated with a higher incidence of rare bleeding disorders.
- The Middle East shows a notable prevalence of consanguineous marriages, contributing to RBDs.
- Limited healthcare resources in developing nations exacerbate the clinical management of RBDs.
Conclusions:
- Consanguinity plays a significant role in the inheritance patterns of rare bleeding disorders.
- Healthcare systems should implement targeted prevention strategies, including genetic counseling for couples considering consanguineous marriage.
- Addressing socioeconomic and healthcare infrastructure limitations is vital for managing RBDs effectively.
Abstract:
Introduction: Rare bleeding disorders (RBDs) are a heterogeneous group of bleeding disorders. Consanguineous marriage is the favorite partnership in many communities among a population of more than a billion. Consanguineous marriages allow the defective recessive genes in RBDs to remain in the family. Clinical approach to RBDs is not as straightforward as typical bleeding disorders, which are secondary to scarcity and variation of RBDs. However, in many developing countries, the limitations of diagnostic facilities, the supply of therapeutic coagulation concentrates, health budgets, and optimal health-care infrastructures may intensify the clinical practice of RBDs.Areas covered: The author addresses the role of consanguineous marriage in the incidence of RBDs and what preventive steps can be considered to minimize the incidence of RBDs. A literature review of PubMed and google Scholar was conducted in November of 2020 using the relevant keywords.Expert opinion: This review addresses the prevalence of consanguineous marriages in Middle Eastern countries and the various reasons behind the coexistence of consanguineous marriage with RBDs. Finally, prevention steps that may be considered by health-care systems to minimize the incidence of rare bleeding disorders have been discussed. Health-care systems should train partners with the intention of consanguineous marriage on the downside of consanguinity.
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