Related Experiment Videos
Pharmacokinetics of bacampicillin using a compartment model with zero-order absorption
S Ripa1, L Ferrante, F Mignini
1Department of Cellular Biology, Faculty of Pharmacy, University of Camerino, Italy.
Chemotherapy
|January 1, 1988
Summary
Bacampicillin, an ampicillin prodrug, shows rapid gastrointestinal absorption. Pharmacokinetic studies in healthy volunteers reveal a short absorption duration and a mean plasma half-life of approximately 1.17 hours.
Area of Science:
- Pharmacology
- Clinical Pharmacy
Background:
- Bacampicillin is an orally administered prodrug of ampicillin.
- Understanding its pharmacokinetic profile is crucial for therapeutic efficacy.
Purpose of the Study:
- To investigate the pharmacokinetics of bacampicillin following a single oral dose in healthy male volunteers.
- To determine key pharmacokinetic parameters such as absorption rate, peak plasma concentration, and elimination half-life.
Main Methods:
- A single oral dose of 1,200 mg bacampicillin was administered to 10 healthy male volunteers.
- Pharmacokinetic analysis was performed using a single-compartment model with zero-order absorption.
- Plasma concentrations and urinary recovery were measured over 24 hours.
Main Results:
- The apparent absorption duration was approximately 1 hour for all subjects.
- Peak plasma concentrations (Cmax) averaged 17.89 ± 1.82 µg/ml.
- The mean plasma half-life (beta-phase) was 1.17 ± 0.14 hours, with a 24-hour urinary recovery of 76.4 ± 3.65%.
Conclusions:
- Bacampicillin is rapidly absorbed from the gastrointestinal tract.
- The determined pharmacokinetic parameters support its use as an effective ampicillin prodrug.