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A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Continuing care describes the variety of health, personal, and social services provided over a prolonged period. The need for continuing care is increasing because people are living longer. Many people do not have families or others to care for them. Continuing care is mainly for patients who are disabled, functionally dependent, or suffering from a terminal disease. It is available within institutional settings or in homes. Examples include nursing centers or facilities, assisted living,...
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Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
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Related Experiment Video

Updated: Nov 7, 2025

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Rational prescribing in community palliative care.

Geoffrey Mitchell

    Australian Prescriber
    |April 29, 2021
    PubMed
    Summary

    Palliative care is essential for all, especially for older patients with multimorbidity. Proactive symptom management and deprescribing are key to preventing morbidity and improving care for those with non-malignant diseases.

    Area of Science:

    • Geriatrics
    • Palliative Medicine
    • Clinical Pharmacology

    Background:

    • Palliative care is crucial for the majority of deaths, often resulting from multimorbidity, frailty, and dementia, rather than cancer.
    • Many patients with non-malignant diseases and their symptoms, such as pain and dyspnea, can be managed proactively.

    Purpose of the Study:

    • To highlight the importance of proactive symptom management and deprescribing in palliative care for older adults with non-malignant conditions.
    • To emphasize the need for healthcare providers to be knowledgeable about medications for symptom control in this population.

    Main Methods:

    • Review of common symptoms and management strategies in non-malignant disease palliative care.
    • Discussion of deprescribing as a method to prevent morbidity.
    Keywords:
    deprescribingend-of-life carepalliative careprimary care

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  • Emphasis on medication management, including starting low and titrating slowly.

    • Main Results:

    • Predictable symptoms in non-malignant disease palliative care can be anticipated and managed proactively.
    • Deprescribing is an effective strategy for reducing morbidity.
    • Judicious medication selection and careful titration are vital for effective symptom control.

    Conclusions:

    • Palliative care is a universal responsibility, particularly for older patients with complex conditions.
    • Proactive planning and deprescribing are superior to reactive symptom management.
    • A focused approach to medication management, starting low and titrating slowly, is essential for optimal patient outcomes.