Testosterone metabolism and its testosterone-dependent activation in the uropygial gland of quail
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J Y Floch1, R F Morfin, J Y Daniel
1Service de Biochimie, Faculté de Médecine, UA 598 du CNRS, Brest, France.
Endocrine Research
|January 1, 1988
Abstract:
The in vitro metabolism in the uropygial gland of the male quail results into large yields of 5 beta-reduced and/or 17 alpha-hydroxylated metabolites. This metabolism was studied in glands of sexually quiescent quails five days after a single intra-muscular injection of testosterone to the birds. This treatment led to an increased production of inactive metabolites (epitestosterone and its 5 beta-reduced metabolites) and to a decrease of unmetabolized testosterone. Thus testosterone controls its own metabolism and by this way means to modulate its action in the uropygial gland of quail.