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A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
A Case of Pseudomyogenic Hemangioendothelioma of the Lower Extremity
Myoung Eun Choi1, Dong Jun Lim1, Sung Eun Chang1
1Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Abstract:
Pseudomyogenic hemangioendothelioma (PMH) is a rare vascular tumor and was recently recognized as a distinct entity. It has a predilection for young male adults and it frequently occurs in distal extremities. Although it is known to follow an indolent course, multi-focal presentation and local recurrence are common. PMH should be differentiated from epithelioid sarcoma, epithelioid hemangioendothelioma, dermatofibrosarcoma protuberans, and rhabdomyosarcoma. Its characteristic immunohistochemical staining pattern and recurrent translocation t(7:19)(q22:q13) are the basis for its diagnosis. Surgical excision is the mainstay treatment, although chemotherapy can be considered in non-operable patients. We present a rare case of a 40-year-old Korean male patient diagnosed with PMH through an excisional biopsy to facilitate the recognition PMH in the clinical practice.
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