Relationship between Serum Osteocalcin Level and Gestational Diabetes Mellitus: A Case-Control Study
Saloumeh Peivandi1, Kamelia Yaghoubinia2, Zahra Kashi3
1Department of Gynecology and Obstetrics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Ethiopian Journal of Health Sciences
|April 29, 2021
Summary
Serum osteocalcin (OC) levels did not differ between pregnant women with and without gestational diabetes mellitus (GDM). This study found no significant association between OC levels and GDM in pregnant individuals.
Area of Science:
- Endocrinology
- Metabolic disorders
- Pregnancy complications
Background:
- Osteocalcin (OC), a bone-specific protein, has potential roles in glucose and fat metabolism.
- Gestational diabetes mellitus (GDM) is a common pregnancy complication affecting maternal and fetal health.
- Investigating biomarkers like OC could offer insights into GDM pathophysiology.
Observation:
- A case-control study compared serum OC levels in pregnant women with and without GDM.
- Participants were screened using a 75-g glucose tolerance test (GTT) between 24-28 weeks of gestation.
- Serum OC levels were measured in relation to vitamin D and calcium levels.
Findings:
- No significant differences in serum OC levels were observed between pregnant women with GDM and those without.
- Age, BMI, and OC levels showed no significant correlations in either the GDM or healthy pregnancy groups.
- This suggests OC may not be a direct indicator for GDM in this cohort.
Implications:
- Current findings suggest serum OC levels are not significantly altered in the presence of GDM.
- Further research is recommended to explore the relationship between OC, insulin resistance, and GDM.
- Understanding such metabolic links may inform future diagnostic or therapeutic strategies for GDM.
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