Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

44
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
44
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

323
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
323
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

65
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
65
Obesity01:24

Obesity

872
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
872
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

44
Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...
44
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

401
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
401

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lymphocyte Micronucleus Formation Is Driven by Inflammation-Induced Oxidative DNA Damage in Oesophageal Cancer Development.

International journal of cancer·2026
Same author

Impact of introducing transnasal endoscopy on expanding diagnostic endoscopy services.

BMJ open quality·2025
Same author

Cryotherapy versus radiofrequency ablation in the treatment of post-chemoradiotherapy patients with recurrence of Barrett's dysplasia.

Clinical endoscopy·2024
Same author

The Weight on Sight: Exploring the Links Between Obesity and Ocular Diseases.

Cureus·2024
Same author

Defining an Ageing-Related Pathology, Disease or Syndrome: International Consensus Statement.

medRxiv : the preprint server for health sciences·2024
Same author

The PIG-A gene mutation assay in human biomonitoring and disease.

Environmental and molecular mutagenesis·2023

Related Experiment Video

Updated: Nov 7, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

601

Obesity management for the gastroenterologist.

Saleem Ansari1, Hasan Haboubi2, Nadim Haboubi3

  • 1Clinical Biochemistry, King's College Hospital NHS Foundation Trust, London, UK.

Frontline Gastroenterology
|April 29, 2021
PubMed
Summary

Obesity is a growing epidemic in the UK, leading to serious gastrointestinal and liver issues. This overview covers obesity

Keywords:
gut hormonesmorbid obesitynutritionobesityobesity surgery

More Related Videos

An Acupoint Catgut-embedding Therapy for Treating Obesity
04:50

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

769
Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
10:05

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

12.3K

Related Experiment Videos

Last Updated: Nov 7, 2025

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

601
An Acupoint Catgut-embedding Therapy for Treating Obesity
04:50

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

769
Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice
10:05

Techniques of Sleeve Gastrectomy and Modified Roux-en-Y Gastric Bypass in Mice

Published on: March 20, 2017

12.3K

Area of Science:

  • Gastroenterology and Hepatology
  • Obesity Medicine
  • Microbiome Research

Background:

  • Obesity is a major public health concern in the UK, reaching epidemic proportions.
  • Obesity is linked to significant gastrointestinal and hepatic complications that may appear before cardiometabolic diseases.
  • These obesity-related complications often go untreated due to a lack of focus on underlying obesity.

Purpose of the Study:

  • To provide an overview of obesity pathophysiology, management, and related complications for gastroenterologists and hepatologists.
  • To highlight the importance of addressing obesity as a primary condition in gastrointestinal and liver disease management.
  • To discuss current and emerging treatment strategies for obesity within the scope of digestive health.

Main Methods:

  • Literature review and synthesis of current research on obesity.
  • Analysis of the role of gastroenterologists and hepatologists in obesity management.
  • Exploration of various treatment modalities including medical, surgical, and endobariatric interventions.
  • Discussion of the gut microbiome's influence on obesity and its complications.

Main Results:

  • Obesity is a complex condition with multifaceted pathophysiology.
  • Gastrointestinal and hepatic complications are common sequelae of obesity.
  • A range of treatment options exist, including lifestyle changes, pharmacotherapy, bariatric surgery, and emerging endobariatric procedures.
  • The gut microbiome plays a crucial role in obesity and metabolic health.

Conclusions:

  • Gastroenterologists and hepatologists are pivotal in managing obesity and its associated gastrointestinal and hepatic complications.
  • Comprehensive management strategies integrating pathophysiology, treatment options, and the gut microbiome are essential.
  • Early and effective intervention for obesity can prevent or mitigate severe health consequences.