Secondary metabolite compounds from Sida genus and their bioactivity
N S Aminah1, E R Laili1, M Rafi2
1Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Komplek Kampus C, Jl. Mulyorejo, Surabaya, 60115, Indonesia.
Heliyon
|April 29, 2021
Summary
The Sida genus of plants contains diverse secondary metabolites like alkaloids and flavonoids. These compounds exhibit significant therapeutic potential, including antimicrobial, antimalarial, and antioxidant activities, offering opportunities for new drug development.
Area of Science:
- Ethnobotany
- Medicinal Chemistry
- Pharmacology
Background:
- Plants are crucial sources for novel therapeutic products and medicines.
- Plant biological properties are attributed to their secondary metabolites.
- The genus Sida (Malvaceae) is globally utilized for its medicinal properties.
Purpose of the Study:
- To review the chemical composition of the Sida genus.
- To summarize the biological effects of Sida species.
- To identify potential research opportunities within the Sida genus.
Main Methods:
- Literature review of scientific journals, books, and electronic databases (PubMed, ScienceDirect, Google Scholar).
- Analysis of secondary metabolite compounds isolated from Sida species.
- Compilation of pharmacological data on extracts and compounds.
Main Results:
- Key secondary metabolites identified include alkaloids, flavonoids, and coumarins.
- Sida extracts and compounds demonstrate a broad spectrum of biological activities.
- Activities include antimalarial, antiplasmodial, antimicrobial, analgesic, antibacterial, antioxidant, vasorelaxant, and wound healing properties.
Conclusions:
- The genus Sida possesses a rich array of secondary metabolites with diverse pharmacological activities.
- These findings highlight the Sida genus as a promising source for the development of new therapeutic agents.
- Further research into Sida's chemical constituents and biological effects is warranted for drug discovery.
