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Convalescent plasma transfusion a promising therapy for coronavirus diseases 2019 (COVID-19): current updates

Henu Kumar Verma1, Batoul Farran2, Lakkakula V K S Bhaskar3

  • 1Stem Cell Lab Institute of Endocrinology and Oncology, Naples, 80131, Italy.

Antibody Therapeutics
|April 29, 2021
PubMed

Insights

Convalescent plasma (CP) offers potential relief for COVID-19 patients when treatments are limited. Further high-quality clinical trials are needed to confirm the efficacy and effectiveness of CP therapy for severe cases.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Critical Care Medicine

Background:

  • The COVID-19 pandemic created an urgent need for effective treatments due to a lack of proven therapies.
  • The escalating global case numbers highlighted the potential of convalescent plasma (CP) as an empirical treatment option.
  • Existing treatments like vaccines and specific drugs were not yet available during the early stages of the COVID-19 outbreak.

Purpose of the Study:

  • To review historical clinical trials involving COVID-19 patients treated with convalescent plasma.
  • To provide precise evidence regarding the efficacy and effectiveness of CP therapy in severe COVID-19 cases.
  • To identify gaps in high-quality clinical evidence for CP treatment in COVID-19.

Main Methods:

  • Systematic review of historical clinical trials.
  • Analysis of data from COVID-19 patients treated with convalescent plasma.
  • Evaluation of the efficacy and effectiveness of CP therapy.

Main Results:

  • While numerous clinical trials are underway, high-quality evidence supporting CP therapy for COVID-19 remains limited.
  • Existing data suggests potential therapeutic benefits, but formal proof of efficacy is still required.
  • Analysis of current trials is necessary to address existing problems and limitations in CP research.

Conclusions:

  • Convalescent plasma (CP) shows promise as a potential treatment for severe COVID-19, particularly when other options are scarce.
  • Healthcare systems should consider using CP therapy cautiously in critically ill COVID-19 patients, based on available evidence.
  • Further rigorous clinical trials are essential to establish definitive proof of efficacy and guide optimal use of CP in COVID-19 management.

Keywords:
COVID-19Clinical trialsconvalescent plasmacorona viruspathogen inactivationserology

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