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The Effect of Curcumin on the Prevention of Myringosclerosis in Rats
Özlem Akkoca1, Selda Kargın Kaytez1, Nihat Yumuşak2
1Department of Otorhinolaryngology, University of Health Sciences Ankara Training and Research Hospital, Ankara, Turkey.
Objective:
The aim of this study was to investigate the preventative effect of oral curcumin (CMN) on myringosclerosis (MS) in an experimental rat model.
Methods:
The study included 21 female Wistar albino rats randomly separated into three groups. Group 1 was given no treatment (control group). In Group 2 and Group 3, the tympanic membrane (TM) was perforated using a sterile ear pick. The rats in Group 3 were administered oral CMN 200 mg/kg/day. All rats were sacrificed after 16 days. Otomicroscopic and histopathologic examinations were performed on the tympanic membranes.
Results:
Histopathologic examinations revealed that there were statistically significant differences between Group 2 and Group 3 in terms of MS degrees (p<0.001) and mean thicknesses of TMs (p<0.001), but there were no differences between Group 1 and Group 3. In respect of MS detected by otomicroscopy, a statistically significant difference was determined between Groups 1 and 2 (p<0.001) and between Groups 2 and 3 (p<0.01), but there was no significant difference between Group 1 and Group 3 (p=0.575).
Conclusion:
Orally administered CMN can prevent myringosclerosis formation in experimentally induced myringotomies.
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