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Updated: Nov 7, 2025

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

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Are opioid receptor antagonists adequate for "Opioid" overdose in a changing reality?

John F Peppin1,2, Joseph V Pergolizzi3,4,5, Albert Dahan6

  • 1Marian University College of Osteopathic Medicine (Clinical Adjunct Professor), Indianapolis, IN, USA.

Journal of Clinical Pharmacy and Therapeutics
|April 29, 2021
PubMed
Abstract

Keywords:
adverse effectnaloxoneopioid antagonistopioid overdosepolysubstance use

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