Related Experiment Video
Updated: Nov 7, 2025
Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
An unexpected in-solution instability of diiodido analogue of picoplatin complicates its biological characterization
Pavel Štarha1, Bohuslav Drahoš1, Radovan Herchel1
1Department of Inorganic Chemistry, Faculty of Science, Palacký University in Olomouc, 17. listopadu 1192/12, 771 46 Olomouc, Czech Republic. pavel.starha@upol.cz.
Abstract:
Complex cis-[PtI2(NH3)(pic)] (1; pic = 2-methylpyridine), a diiodido analogue of clinically studied picoplatin (2), is unstable in solution, which is intriguingly connected with the release of its pic ligand. This observation complicates the biological testing of e.g. cytotoxicity in human cancer cells for 1.
More Related Videos
13:17In Vitro and In Vivo Evaluation of Photocontrolled Biologically Active Compounds - Potential Drug Candidates for Cancer Photopharmacology
Published on: September 29, 2023
10:16Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
Published on: February 8, 2017