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Updated: Nov 7, 2025

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
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Elaborating the Physiological Role of YAP as a Glucose Metabolism Regulator:A Systematic Review

Ardo Sanjaya1,2, Hanna Goenawan3,4, Iwan Setiawan3

  • 1Graduate School of Biomedical Science, PMDSU Program Batch V, Universitas Padjajaran, Bandung, Indonesia.

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
|April 29, 2021
PubMed

Insights

Yes-associated protein (YAP), a Hippo pathway effector, regulates glucose metabolism by controlling key enzymes and transporters. YAP

Area of Science:

  • Cellular Biology
  • Metabolic Regulation
  • Oncology

Background:

  • The Hippo pathway effector, Yes-associated protein (YAP), is known for its role in organ size control and oncogenesis.
  • Emerging research indicates YAP's involvement in regulating glucose metabolism within cancer cells.

Purpose of the Study:

  • To review and synthesize current literature on YAP's role in controlling glucose metabolism.
  • To assess the translatability of YAP's metabolic functions from cancer to physiological conditions.

Main Methods:

  • Literature review of studies investigating YAP's impact on glucose metabolism.
  • Analysis of YAP's regulation of genes involved in glycolysis, gluconeogenesis, and glucose transport.
  • Examination of the interplay between YAP activity and physiological regulators of glucose.

Main Results:

  • YAP transcriptionally upregulates most genes critical for glucose metabolism, including enzymes and glucose transporters (GLUT family).
  • YAP influences glycolysis and gluconeogenesis, except for enolase and pyruvate kinase.
  • YAP activity is modulated by glucose levels, hypoxia, and hormones (insulin, glucagon), which also depend on YAP for their effects.

Conclusions:

  • YAP acts as a central regulator of glucose metabolism, governing both enzymatic pathways and glucose transport.
  • YAP strategically integrates signals from various glucose-regulating pathways.
  • Further validation in physiological contexts and metabolic disorders may position YAP as a therapeutic target.
Keywords:
Carbohydrate metabolism; Gluconeogenesis; Glucose transporter; Glycolysis; Yes-associated protein

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