Motor unit firing rates during constant isometric contraction: establishing and comparing an age-related pattern...

Motor unit (MU) firing rates (FRs) are lower in aged adults, compared with young, at relative voluntary contraction intensities. However, from a variety of independent studies of disparate muscles, the age-related degree of difference in FR among muscles is unclear. Using a standardized statistical approach with data derived from primary studies, we quantified differences in FRs across several muscles between younger and older adults. The data set included 12 different muscles in young (18-35 yr) and older adults (62-93 yr) from 18 published and one unpublished study. Experiments recorded single MU activity from intramuscular electromyography during constant isometric contraction at different (step-like) voluntary intensities. For each muscle, FR ranges and FR variance explained by voluntary contraction intensity were determined using bootstrapping. Dissimilarity of FR variance among muscles was calculated by Euclidean distances. There were threefold differences in the absolute frequency of FR ranges across muscles in the young (soleus 8-16 and superior trapezius 20-49 Hz), but in the old, FR ranges were more similar and lower for nine out of 12 muscles. In contrast, the explained FR variance from voluntary contraction intensity in the older group had 1.6-fold greater dissimilarity among muscles than the young (P < 0.001), with FR variance differences being muscle dependent. Therefore, differences between muscle FR ranges were not explained by how FRs scale to changes in voluntary contraction intensity within each muscle. Instead, FRs were muscle dependent but were more dissimilar among muscles in the older group in their responsiveness to voluntary contraction intensity.NEW & NOTEWORTHY The mean frequency of motor unit firing rates were compared systematically among several muscles and between young and older adults from new and published data sets. Firing rates among muscles were lower and more similar during voluntary isometric contraction in older than younger adults. Firing rate responses from voluntary contraction intensity were muscle dependent and more dissimilar among muscles in the older than young adults.