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Oregano essential oil inhibits Candida spp. biofilms

Mayram Hacioglu1, Ozlem Oyardi1, Alpcan Kirinti1

  • 1Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul University, Beyazit, Istanbul, 34116, Turkey.

Zeitschrift Fur Naturforschung. C, Journal of Biosciences
|April 29, 2021
PubMed

Insights

Oregano oil exhibits significant antifungal and antibiofilm properties against Candida species. This natural compound effectively inhibits biofilm formation and disrupts existing biofilms, offering a promising therapeutic agent.

Area of Science:

  • Microbiology
  • Natural Product Chemistry

Background:

  • Biofilms formed by Candida species are a major cause of persistent infections, often associated with medical devices.
  • Developing effective strategies against these biofilms is crucial for treating recalcitrant Candida infections.

Purpose of the Study:

  • To investigate the antifungal and antibiofilm activities of oregano oil (Origanum onites) against Candida species.
  • To evaluate the efficacy of oregano oil in preventing and eradicating Candida biofilms.

Main Methods:

  • Screening of essential oils for antifungal activity against Candida spp.
  • Detailed investigation of oregano oil's effects on Candida biofilm adhesion, formation, and mature biofilms.
  • Testing oregano oil against dual-species biofilms of Candida albicans and Staphylococcus aureus.

Main Results:

  • Oregano oil demonstrated the most potent antifungal activity among tested essential oils.
  • Oregano oil significantly inhibited Candida spp. biofilm adhesion and formation, with up to 50% reduction on pre-coated surfaces.
  • Effective antibiofilm activity was observed against dual-species biofilms of Candida albicans and Staphylococcus aureus.

Conclusions:

  • Origanum onites essential oil possesses significant antibiofilm effects against Candida species.
  • The study provides the first evidence of Origanum onites essential oil's inhibitory effects on Candida spp. biofilms.
  • Oregano oil shows promise as a natural agent for combating Candida-related biofilm infections.
Keywords:
Candida spp.Origanum onitesbiofilmessential oiloregano

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