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Updated: Nov 7, 2025

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

SARS-CoV-2 serology testing: Progress and challenges.

Aria C Shi¹, Ping Ren²

¹Johns Hopkins University School of Medicine, Baltimore, MD, United States of America.

Journal of Immunological Methods

|April 29, 2021

Summary

This summary is machine-generated.

The COVID-19 pandemic requires effective serology testing to monitor neutralizing antibody levels for vaccine efficacy and herd immunity. Reliable testing is crucial for tracking immunity in both infected and vaccinated individuals to prevent reinfection.

Keywords:

Binding antibodies COVID-19 Neutralizing antibodies SARS-CoV-2 Serology testing

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Last Updated: Nov 7, 2025

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Dynamic Monitoring of Seroconversion using a Multianalyte Immunobead Assay for Covid-19

Published on: February 16, 2022

Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling

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Published on: June 23, 2022

Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter

Detection of SARS-CoV-2 Receptor-Binding Domain Antibody using a HiBiT-Based Bioreporter

Published on: August 12, 2021

Area of Science:

Immunology
Epidemiology
Public Health

Background:

The COVID-19 pandemic has had profound global social and economic impacts.
Achieving herd immunity through vaccination is critical for pandemic resolution.
Asymptomatic infections are common, necessitating reliable methods to assess immunity.

Purpose of the Study:

To review the current landscape of COVID-19 serology testing.
To discuss the challenges and limitations of existing serological assays.
To propose future directions for improving COVID-19 serology testing.

Main Methods:

Review of existing literature and FDA Emergency Use Authorizations (EUA) for COVID-19 serology tests.
Analysis of the role of neutralizing antibodies in protective immunity.
Discussion of the importance of monitoring antibody titers over time.

Main Results:

Numerous serological testing platforms have been developed by academia and industry.
Many platforms have received FDA Emergency Use Authorization (EUA).
Neutralizing antibody levels are key indicators of protective immunity.

Conclusions:

Serology testing is essential for diagnosing past infections and monitoring immunity in vaccinated individuals.
Waning antibody levels can lead to vulnerability to reinfection.
Continued development and validation of serology tests are needed to combat the COVID-19 pandemic effectively.