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α-Glucosidic hydroquinone derivatives from Viburnum erosum
Jinyoung Park1, Jiho Lee1, Hyeon Seok Jang1
1College of Pharmacy, Kangwon National University, Chuncheon, 24341, Republic of Korea.
Abstract:
Six undescribed compounds (1-6) were isolated from the leaves of Viburnum erosum along with four known compounds 7-10. The structures were determined by NMR and MS spectroscopic analyses, and their absolute configurations were established by chemical and spectroscopic methods. Compounds 1-6 were α-glucosidic hydroquinone derivatives with different linear monoterpenoid structures. Compounds 1-10 were also evaluated for their tyrosinase inhibitory activities, and 10 showed potent inhibition of tyrosinase enzyme with IC50 value of 37.9 μM compared to 47.6 μM of the positive control (β-arbutin).
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