Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

3.1K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
3.1K
Activation of Integrins01:15

Activation of Integrins

4.3K
Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
4.3K
Integrins01:10

Integrins

4.6K
Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
Some ECM proteins assemble into a basement membrane to which the remaining components adhere. Proteoglycans typically form the bulk of the ECM while fibrous proteins, like collagen,...
4.6K
Liver Regeneration01:24

Liver Regeneration

3.7K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.7K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

8.2K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
8.2K
Anchoring Junctions01:03

Anchoring Junctions

4.4K
Anchoring junctions are multiprotein complexes that help cells connect to other cells and the extracellular matrix. Anchoring junctions are present on the lateral and basal surfaces of cells, providing strong and flexible connections. Focal adhesions are often formed due to cell interactions with the ECM substrata, which initiate signal transduction via kinase cascades and other mechanisms. Together, they provide stability and tissue integrity. There are three types of anchoring junctions:...
4.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanisms of APOBEC3 Packaging into HIV-1.

Viruses·2026
Same author

Integrative approaches for the structure-based functional understanding of the ethylene response in plants.

The Plant journal : for cell and molecular biology·2026
Same author

Chat-Driven Computational (Bio)chemistry: Using LLM Agents to Accelerate Bio- and Chemoinformatics.

Journal of chemical information and modeling·2026
Same author

G521 is the gatekeeper and a key transmembrane domain contact residue of <i>Candida albicans</i> Cdr1.

mBio·2026
Same author

An Integrated Engineering Approach to Intensify the Biocatalytic Metaraminol Synthesis.

ChemSusChem·2026
Same author

Evidence for Epibatidine Binding to the Desensitization Gate in α7 nAChR from Molecular Dynamics Simulations and Cryo-EM.

Journal of chemical information and modeling·2026

Related Experiment Video

Updated: Nov 7, 2025

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

16.4K

Liver cell hydration and integrin signaling.

Michele Bonus1, Dieter Häussinger2, Holger Gohlke1,3,4

  • 1Institute for Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany.

Biological Chemistry
|April 29, 2021
PubMed
Summary

Liver cell hydration, or cell volume, dynamically impacts liver cell function. This review highlights β1 integrins as key sensors linking cell volume changes to liver signaling and bile acid pathways.

Keywords:
bile acidscell swellingfunctional selectivitymechanotransductionmolecular dynamics simulationstauroursodeoxycholate

More Related Videos

A High-throughput Cell Microarray Platform for Correlative Analysis of Cell Differentiation and Traction Forces
12:04

A High-throughput Cell Microarray Platform for Correlative Analysis of Cell Differentiation and Traction Forces

Published on: March 1, 2017

9.9K
Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
07:40

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions

Published on: June 29, 2016

8.8K

Related Experiment Videos

Last Updated: Nov 7, 2025

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
09:14

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

Published on: June 13, 2014

16.4K
A High-throughput Cell Microarray Platform for Correlative Analysis of Cell Differentiation and Traction Forces
12:04

A High-throughput Cell Microarray Platform for Correlative Analysis of Cell Differentiation and Traction Forces

Published on: March 1, 2017

9.9K
Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
07:40

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions

Published on: June 29, 2016

8.8K

Area of Science:

  • Hepatology
  • Cell Physiology
  • Mechanobiology

Background:

  • Liver cell volume is a dynamic physical parameter.
  • Cell volume changes rapidly due to hormones, nutrients, and oxidative stress.
  • Volume changes modulate critical liver cell functions.

Purpose of the Study:

  • To review research on liver cell volume regulation.
  • To emphasize the role of β1 integrins as osmo-mechanosensors.
  • To explore the connection between cell volume, liver function, and bile acid signaling.

Main Methods:

  • Review of existing research and experimental data.
  • Focus on the function of β1 integrins in hepatocytes.
  • Analysis of osmosignaling pathways in the liver.

Main Results:

  • Liver cell hydration is a significant modulator of cell function.
  • Mechanotransduction (osmosensing) links cell volume to signaling cascades (osmosignaling).
  • β1 integrins act as crucial osmo-mechanosensors in the liver.

Conclusions:

  • Cell volume is an integral physical parameter influencing liver cell function.
  • β1 integrins play a key role in sensing cell volume changes and mediating liver responses.
  • Understanding osmosignaling is vital for liver physiology and disease.