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Related Experiment Video

Updated: Nov 7, 2025

Three-Dimensional In Vitro Biomimetic Model of Neuroblastoma Using Collagen-Based Scaffolds
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Artificial Tumor Microenvironments in Neuroblastoma.

Colin H Quinn1, Andee M Beierle2, Elizabeth A Beierle1

  • 1Division of Pediatric Surgery, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35205, USA.

Cancers
|April 30, 2021
PubMed
Summary

Understanding the tumor microenvironment (TME) is crucial for advancing neuroblastoma treatments. Three-dimensional (3D) bioprinting offers a novel approach to incorporate TME components for developing effective pediatric cancer therapies.

Keywords:
cancer associated fibroblastsmesenchymal stromal cellsneuroblastomathree-dimensional bioprintingthree-dimensional modelingtumor associated macrophagestumor microenvironment

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Area of Science:

  • Oncology
  • Biotechnology
  • Cancer Research

Background:

  • The tumor microenvironment (TME) significantly influences neuroblastoma progression and therapeutic resistance.
  • Current preclinical models often fail to adequately represent the TME's complexity.
  • A deeper understanding of TME components is essential for developing novel neuroblastoma therapeutics.

Purpose of the Study:

  • To review the major components of the neuroblastoma TME.
  • To explore the application of three-dimensional (3D) bioprinting in modeling the TME for neuroblastoma research.
  • To highlight the potential of 3D bioprinting for improving neuroblastoma treatment development.

Main Methods:

  • Review of existing literature on neuroblastoma TME components.
  • Examination of three-dimensional (3D) bioprinting techniques and their integration with TME elements.
  • Analysis of current studies utilizing 3D bioprinting for neuroblastoma research.

Main Results:

  • The TME comprises extracellular matrix, cytokines, immune cells, and vasculature that promote aggressive neuroblastoma phenotypes.
  • Traditional 2D and in vivo models have limitations in capturing TME contributions.
  • 3D bioprinting is emerging as a promising method to incorporate TME components into cancer models.

Conclusions:

  • Incorporating TME elements into preclinical models is vital for advancing neuroblastoma therapy.
  • 3D bioprinting provides a powerful platform for creating more accurate neuroblastoma models that include TME interactions.
  • This approach holds significant promise for developing innovative and effective treatments for pediatric neuroblastoma.