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BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19
Rui-Ru Ji1, Yajin Qu2, Hua Zhu2
1Shanghai Fosun Pharmaceutical Industrial Development, Co. Ltd., 1289 Yishan Road, Shanghai 200233, China.
Vaccines
|April 30, 2021
Abstract:
BNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers in neutralizing antibodies against SARS-CoV-2, which correlated with viral clearance and alleviated lung lesions in these mice after viral challenge.
