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Targeting the Metabolic Adaptation of Metastatic Cancer
Josep Tarragó-Celada1, Marta Cascante1,2,3
1Department of Biochemistry and Molecular Biomedicine, Institute of Biomedicine of Universitat de Barcelona (IBUB), Faculty of Biology, Universitat de Barcelona, 08028 Barcelona, Spain.
Abstract:
Metabolic adaptation is emerging as an important hallmark of cancer and metastasis. In the last decade, increasing evidence has shown the importance of metabolic alterations underlying the metastatic process, especially in breast cancer metastasis but also in colorectal cancer metastasis. Being the main cause of cancer-related deaths, it is of great importance to developing new therapeutic strategies that specifically target metastatic cells. In this regard, targeting metabolic pathways of metastatic cells is one of the more promising windows for new therapies of metastatic colorectal cancer, where still there are no approved inhibitors against metabolic targets. In this study, we review the recent advances in the field of metabolic adaptation of cancer metastasis, focusing our attention on colorectal cancer. In addition, we also review the current status of metabolic inhibitors for cancer treatment.
Insights
Metabolic adaptation fuels cancer metastasis, particularly in colorectal cancer. Targeting these metabolic pathways offers a promising therapeutic strategy for metastatic disease.
Area of Science:
- Oncology
- Metabolism
- Cancer Biology
Background:
- Metabolic adaptation is a key characteristic of cancer and metastasis.
- Metabolic alterations are crucial in breast and colorectal cancer metastasis.
- Targeting metastatic cells is vital for reducing cancer-related mortality.
Purpose of the Study:
- Review recent advances in cancer metastasis metabolic adaptation.
- Focus on metabolic adaptation in colorectal cancer metastasis.
- Examine current metabolic inhibitors for cancer treatment.
Main Methods:
- Literature review of metabolic adaptation in cancer metastasis.
- Focus on colorectal cancer and its metastatic pathways.
- Analysis of existing metabolic inhibitors in cancer therapy.
Main Results:
- Metabolic adaptation is a critical hallmark of cancer metastasis.
- Colorectal cancer metastasis involves significant metabolic alterations.
- Targeting cancer cell metabolism presents a promising therapeutic avenue.
Conclusions:
- Understanding metabolic adaptation is key to developing new cancer therapies.
- Targeting metabolic pathways in metastatic colorectal cancer is a promising strategy.
- Further research into metabolic inhibitors is needed for effective cancer treatment.
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