Related Experiment Video

Updated: Nov 7, 2025

Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue
06:56

Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue

Published on: July 21, 2023

2.6K

Association between Vascular Inflammation and Inflammation in Adipose Tissue, Spleen, and Bone Marrow in Patients

Hannah Kaiser1,2,3, Amanda Kvist-Hansen1,2,3, Martin Krakauer4,5

  • 1Department of Cardiology, Herlev and Gentofte Hospital, 2900 Hellerup, Denmark.

Life (Basel, Switzerland)
|April 30, 2021
PubMed

Insights

Psoriasis patients show links between vascular inflammation and inflammation in adipose tissues, spleen, and bone marrow. These findings suggest shared inflammatory pathways contributing to cardiovascular disease risk.

Area of Science:

  • Cardiovascular Medicine
  • Inflammation Research
  • Dermatology

Background:

  • Psoriasis shares inflammatory pathways with atherosclerotic cardiovascular disease (CVD).
  • Potential links exist between vascular inflammation and inflammation in adipose tissues, spleen, and bone marrow.

Purpose of the Study:

  • To investigate associations between vascular inflammation and inflammation in adipose tissues, spleen, and bone marrow in psoriasis patients.
  • To utilize 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) for inflammation assessment.

Main Methods:

  • Recruited 83 psoriasis patients, with half having established CVD.
  • Measured inflammation via 18F-FDG uptake in the aorta, visceral (VAT), subcutaneous (SAT), and pericardial (PAT) adipose tissues, spleen, and bone marrow.
  • Performed carotid ultrasound imaging.

Main Results:

  • Vascular inflammation correlated significantly with FDG uptake in VAT, SAT, PAT, spleen, and bone marrow.
  • Associations remained significant after adjusting for age, sex, BMI, and hsCRP.
  • No correlations were found between vascular inflammation and carotid intima-media thickness or plaque presence.

Conclusions:

  • An inflammatory link exists between vascular and adipose tissues, spleen, and bone marrow in psoriasis patients.
  • These findings highlight potential systemic inflammatory mechanisms in psoriasis-associated CVD.
  • Further research into these pathways may reveal novel therapeutic targets.

Keywords:
18F-FDG-PET/CTadipose tissuecardiovascular diseasepsoriasisvascular inflammation

More Related Videos

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model12:23

Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model

Published on: April 24, 2020

20.3K
Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

594

Related Concept Videos

Inflammation01:38

Inflammation

Overview
57.1K
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.7K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
144
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
13.7K
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
133
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.9K