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A Protocol for Analyzing Hepatitis C Virus Replication
Published on: June 26, 2014
Telemedicine Chronic Viral Hepatitis C Treatment during the Lockdown Period in Romania: A Pilot Study
Irina Paula Doica1, Dan Nicolae Florescu1, Carmen Nicoleta Oancea2
1Gastroenterology Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Insights
Telemedicine effectively monitored Hepatitis C virus (HCV) patients during COVID-19 lockdowns in Romania, achieving 100% medication adherence and sustained virologic response (SVR). This approach offers a reliable alternative for chronic disease management.
Area of Science:
- Hepatology
- Infectious Diseases
- Digital Health
Background:
- The COVID-19 pandemic disrupted chronic disease management, including Hepatitis C virus (HCV) eradication efforts.
- Neglect of chronic diseases necessitates alternative strategies for therapy implementation and monitoring.
- HCV treatment requires continuous monitoring, which was challenged by pandemic-related restrictions.
Purpose of the Study:
- To establish a telemedicine program for monitoring HCV-infected patients in Romania during the COVID-19 outbreak and lockdown.
- To assess the feasibility and effectiveness of telemedicine for HCV antiviral therapy management.
- To compare medication adherence and treatment outcomes between telemedicine and traditional monitoring.
Main Methods:
- A pilot telemedicine program was implemented for previously diagnosed HCV patients.
- Patient characteristics and medication adherence were assessed and compared to the pre-pandemic period.
- A satisfaction questionnaire was administered post-treatment, and sustained virologic response (SVR) was evaluated.
Main Results:
- The study included 41 HCV patients in the telemedicine program.
- Medication adherence was 100% in the telemedicine group, significantly higher than in 2019.
- Sustained virologic response (SVR) was 100% for all participants, with high patient satisfaction (4.92/5).
- Older patients showed lower engagement but achieved similar SVR and adherence rates.
Conclusions:
- Telemedicine provides a reliable and effective alternative for HCV therapy monitoring, especially during public health crises.
- This pilot study demonstrates the first telemedicine program for HCV management in Romania.
- The findings support the continued use of telemedicine for HCV treatment beyond the pandemic.
Abstract:
The COVID-19 pandemic is currently delaying the process of chronic hepatitis C (HCV) eradication, since most of the chronic diseases are neglected. Thus, there is a need for alternative programs for HCV therapy implementation and disease monitoring. Our aim was to provide a multidisciplinary approach, so that HCV-infected patients from distant locations may benefit from HCV antivirals during the COVID-19 outbreak and within the lockdown period in Romania. Previously diagnosed HCV patients willing to participate in this telemedicine pilot study were included. Patient characteristics and medical adherence were assessed and compared to the year preceding the pandemic. We proposed a multidisciplinary approach by using a telemedicine program for HCV therapy monitoring. Patients also received a satisfaction questionnaire after delivering the sustained virologic response (SVR) result. A total of 41 patients agreed to participate in this study. The medication adherence was 100% for patients included in the telemedicine group, with a statistically significant difference from the medication adherence of the patients treated in 2019. The satisfaction item score was 4.92 out of 5 and our results (r = -0.94, p < 0.0001) suggested that older patients embraced the telemedicine program less, but with the same success in terms of SVR (100%) and medication adherence (100%). Our pilot study offers the first example of a telemedicine program in Romania for HCV therapeutic management. During the lockdown period, telemedicine has served as a reliable tool and novel alternative for conventional monitoring of patients treated with direct antiviral agents and should be further considered even following the pandemic.
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