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Mediterranean Diet Implementation to Protect against Advanced Lung Cancer Index (ALI) Rise: Study Design and

Aristea Gioxari1, Dimitrios Tzanos1, Christina Kostara2

  • 1Department of Dietetics and Nutritional Science, School of Health Science and Education, Harokopio University, 17671 Athens, Greece.

International Journal of Environmental Research and Public Health
|April 30, 2021
PubMed

Insights

The Mediterranean diet (MD) shows promise in managing inflammation and improving nutritional status in advanced lung cancer (LC) patients. Preliminary results indicate a reduced inflammation index and better glucose control with MD.

Area of Science:

  • Oncology
  • Nutrition Science
  • Inflammation Research

Background:

  • The Mediterranean diet (MD) is linked to reduced lung cancer (LC) risk.
  • Inflammatory and nutritional status are critical in advanced LC prognosis.
  • Limited data exists on MD's impact on LC patient biomarkers.

Purpose of the Study:

  • To evaluate the preliminary effects of a 3-month Mediterranean diet (MD) intervention on inflammatory and nutritional markers in advanced lung cancer (LC) patients.
  • To compare the outcomes between a personalized MD plan and general nutritional guidelines.

Main Methods:

  • Prospective randomized controlled trial involving 30 patients with advanced (stages III-IV) small-cell or non-small-cell LC.
  • Participants were randomized to either a control group (general guidelines) or an MD group (personalized plan).
  • Assessed medical/dietary history, anthropometrics, blood biomarkers, and antioxidant vitamins.

Main Results:

  • The advanced lung cancer inflammation index (ALI) was significantly higher in the control group compared to the MD group (p = 0.003).
  • Platelet count significantly decreased in the MD group (p = 0.044).
  • Serum glucose levels were significantly higher in the control group than the MD group (p = 0.017).

Conclusions:

  • Personalized Mediterranean diet (MD) implementation for 3 months shows potential in regulating prognostic biomarkers for advanced lung cancer (LC).
  • MD may help modulate inflammation and glucose metabolism in LC patients.
  • Further research from the ongoing trial will provide comprehensive insights into MD's effects on LC patient inflammatory, antioxidant, and nutritional status.
Keywords:
ALIMediterranean dietantioxidant vitaminsinflammationlung cancernutritional statusplatelet count

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