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Statin Use Is Associated with a Decreased Risk of Mortality among Patients with COVID-19

Chieh-Chen Wu1,2, An-Jen Lee1,3, Chun-Hsien Su4

  • 1Department of Healthcare Information and Management, School of Health Technology, Ming Chuan University, Taipei 333, Taiwan.

Journal of Clinical Medicine
|April 30, 2021
PubMed

Insights

Statin use significantly reduces the risk of mortality in COVID-19 patients. This systematic review found that statins, whether used before or after admission, lower the chances of death from COVID-19.

Area of Science:

  • Cardiovascular Research
  • Infectious Disease Epidemiology
  • Pharmacological Interventions

Background:

  • Epidemiological studies on statin use and COVID-19 mortality risk have yielded conflicting results.
  • Clarifying the association between statin therapy and mortality in COVID-19 patients is crucial for clinical practice.

Purpose of the Study:

  • To systematically evaluate the association between statin use and mortality risk in patients diagnosed with COVID-19.
  • To synthesize evidence from published literature to provide a clearer understanding of statins' impact on COVID-19 outcomes.

Main Methods:

  • A comprehensive systematic literature search was performed across major databases (PubMed, EMBASE, Scopus, Web of Science) from February 2020 to February 2021.
  • Studies were screened by two independent reviewers following PRISMA guidelines, with meta-analysis used to calculate pooled risk ratios (RRs) and 95% confidence intervals (CIs).
  • Heterogeneity among studies was assessed using the Q and I statistics.

Main Results:

  • Out of 28 assessed studies, 22 met the inclusion criteria for the meta-analysis.
  • Statin use was significantly associated with a reduced risk of mortality in COVID-19 patients (adjusted RR = 0.64; 95% CI: 0.57-0.72).
  • Both pre-admission and post-admission statin use demonstrated a significant reduction in mortality risk (RR 0.69 and 0.57, respectively).

Conclusions:

  • This systematic review provides robust evidence that statin use is linked to decreased mortality among individuals with COVID-19.
  • Further confirmation through randomized controlled trials is recommended to definitively establish the causal relationship between statin use and COVID-19 mortality reduction.
Abstract

Keywords:
COVID-19SARS-CoV-2diabetesmortality riskstatin

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