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Acute MCPP intoxication: report of two cases.

J Meulenbelt1, J H Zwaveling, P van Zoonen

  • 1National Poison Control Centre, National Institute of Public Health and Environmental Hygiene, Bilthoven, The Netherlands.

Human Toxicology
|May 1, 1988
PubMed
Summary
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Two patients experienced severe poisoning from MCPP, a phenoxy herbicide, exhibiting central nervous system issues, respiratory problems, and hypotension. Their MCPP plasma elimination half-life was approximately 17 hours, indicating a slow recovery process.

Area of Science:

  • Toxicology
  • Pharmacokinetics

Background:

  • Phenoxy herbicides, such as MCPP (mecoprop), are widely used pesticides.
  • Overexposure can lead to significant health risks, necessitating a deeper understanding of their toxicological profiles.

Observation:

  • Two cases of severe MCPP intoxication are presented.
  • Patients exhibited central nervous system depression, respiratory compromise, muscle cramps, rhabdomyolysis, and acute renal failure.
  • A significant drop in blood pressure was observed, attributed to reduced peripheral vascular resistance in one case.

Findings:

  • MCPP plasma concentration reached 298 mg/l in one patient 3-4 hours post-ingestion.
  • The estimated plasma elimination half-life (t1/2) of MCPP was approximately 17 hours.
  • MCPP plasma elimination kinetics appear to follow first-order kinetics.

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Implications:

  • Severe MCPP poisoning can cause life-threatening multi-organ dysfunction.
  • Understanding MCPP pharmacokinetics is crucial for managing intoxication and predicting patient outcomes.
  • This case report highlights the critical need for prompt medical intervention in severe herbicide exposure incidents.