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Lipoprotein Abnormalities in Chronic Kidney Disease and Renal Transplantation

Carlo Maria Barbagallo1, Angelo Baldassare Cefalù1, Antonina Giammanco1

  • 1Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties-University of Palermo, Via del Vespro, 127, 90127 Palermo, Italy.

Life (Basel, Switzerland)
|April 30, 2021
PubMed

Insights

Chronic kidney disease (CKD) is linked to cardiovascular disease (CVD) due to lipid and lipoprotein abnormalities. Managing these dyslipidemias may improve outcomes for CKD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Lipid Metabolism

Background:

  • Chronic kidney disease (CKD) is a significant risk factor for cardiovascular disease (CVD).
  • Patients with advanced CKD often exhibit dyslipidemia, characterized by lipid and lipoprotein alterations.
  • These alterations play a crucial role in the development of CVD in CKD patients.

Purpose of the Study:

  • To review lipid and lipoprotein disturbances in CKD.
  • To analyze the relationship between these disturbances and CKD progression.
  • To discuss the impact of hypolipidemic treatments on CVD in CKD patients.

Main Methods:

  • Literature review focusing on lipid metabolism in CKD.
  • Analysis of lipoprotein abnormalities and their association with CVD.
  • Examination of treatment strategies for dyslipidemia in CKD.

Main Results:

  • Hypertriglyceridemia is a primary lipid disorder in CKD, alongside other lipoprotein abnormalities.
  • Impaired enzyme pathways and proteins affect lipoprotein metabolism in CKD.
  • Renal transplantation can lead to hypercholesterolemia.

Conclusions:

  • Lipid and lipoprotein disturbances are integral to CKD pathophysiology and CVD risk.
  • Understanding these alterations is key for managing CKD progression and cardiovascular complications.
  • Hypolipidemic treatments offer potential strategies to alter the natural history of CVD in CKD patients.

Keywords:
cardiovascular diseasechronic kidney diseaselipidslipoproteins

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