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Related Concept Videos

Tumor Progression02:07

Tumor Progression

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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
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Issues And Trends In Healthcare Delivery System01:29

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The issues and trends in healthcare delivery are constantly changing. The COVID-19 pandemic is one recent issue that wreaked havoc on healthcare systems, causing a shortage of healthcare workers, high demand for medicines and supplies, and increased medical expenditure due to a lack of insurance. Other issues include rising healthcare costs and care fragmentation.
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Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
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COPD: Pathogenesis and Clinical Features01:20

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Related Experiment Video

Updated: Nov 7, 2025

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Hyperprogressive Disease: Main Features and Key Controversies.

Hugo Arasanz1,2, Miren Zuazo1, Ana Bocanegra1

  • 1Oncoimmunology Group, Navarrabiomed, Fundación Miguel Servet-Public University of Navarre, IdiSNA, 31008 Pamplona, Spain.

International Journal of Molecular Sciences
|April 30, 2021
PubMed
Summary
This summary is machine-generated.

Immunotherapy can cause hyperprogressive disease, a rapid tumor growth pattern. Further research is needed to understand its mechanisms and impact across different cancer types.

Keywords:
cancercheckpoint inhibitorshyperprogressive diseaseimmunotherapysolid tumors

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Area of Science:

  • Oncology
  • Immunology
  • Radiology

Background:

  • Immunotherapy is a key cancer treatment.
  • Hyperprogressive disease (HPD) is a new response pattern.
  • HPD involves accelerated tumor growth post-treatment.

Purpose of the Study:

  • Review publications on hyperprogressive disease.
  • Critically analyze controversial aspects of HPD.
  • Discuss HPD's relationship with immunotherapy.

Main Methods:

  • Literature review of relevant studies.
  • Critical analysis of existing definitions and criteria for HPD.
  • Examination of proposed cellular and molecular mechanisms.

Main Results:

  • Several definitions for HPD exist, mainly radiological.
  • Mechanisms of HPD remain unclear.
  • HPD incidence and prognosis may vary by cancer type.

Conclusions:

  • HPD is a debated phenomenon in cancer immunotherapy.
  • Distinguishing HPD from aggressive cancer progression is challenging.
  • Further research is crucial for understanding HPD's role and management.