[Study of antibiotic sensitivity in 34 strains of large colony mycoplasma (author's transl)]
Abstract:
The application of Steer's technic to large colony mycoplasma for the study of antibiotic sensitivities, permitted us to compare the activity of various molecules inhibiting protein synthesis. Among large colony mycoplasmas, only mycoplasma pneumoniae is sensitive to erythromycin but we have already isolated a strain resistant at 400 microgram/ml. This should be remembered during treatment of mycoplasma pneumoniae infections. This species always remains sensitive to tetracycline. Among the latter, doxycyclin and minocyclin are preferred, firstly for their greater efficacy in vitro and secondly their better pharmacodynamic criteria. Gentamicin, tobramycin and chloramphenicol are also active in vitro. No trial in vivo has been carried out.
Insights
Researchers studied antibiotic sensitivities in large colony mycoplasmas. Mycoplasma pneumoniae is sensitive to erythromycin, but resistant strains exist, necessitating careful treatment choices.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Background:
- Large colony mycoplasmas, including Mycoplasma pneumoniae, are significant pathogens.
- Understanding their antibiotic sensitivities is crucial for effective treatment.
- Protein synthesis inhibitors are a key class of antibiotics used against these bacteria.
Purpose of the Study:
- To evaluate the in vitro antibiotic sensitivities of large colony mycoplasmas, focusing on protein synthesis inhibitors.
- To compare the efficacy of various antibiotics against Mycoplasma pneumoniae.
- To identify preferred antibiotic choices for Mycoplasma pneumoniae infections.
Main Methods:
- Application of Steer's technique for antibiotic sensitivity testing.
- In vitro susceptibility testing of large colony mycoplasma isolates.
- Comparative analysis of different protein synthesis inhibiting molecules.
Main Results:
- Mycoplasma pneumoniae demonstrated sensitivity to erythromycin, but a resistant strain (400 µg/ml) was identified.
- Tetracyclines, particularly doxycycline and minocycline, showed consistent sensitivity and favorable pharmacodynamic properties.
- Gentamicin, tobramycin, and chloramphenicol exhibited in vitro activity, but in vivo data is lacking.
Conclusions:
- The emergence of erythromycin-resistant Mycoplasma pneumoniae necessitates consideration during clinical treatment.
- Tetracyclines, especially doxycycline and minocycline, are recommended for Mycoplasma pneumoniae infections due to in vitro efficacy and pharmacodynamics.
- Further in vivo studies are required to validate the efficacy of other tested antibiotics.
