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The Anticancer Effects of Flavonoids through miRNAs Modulations in Triple-Negative Breast Cancer

Getinet M Adinew1, Equar Taka1, Patricia Mendonca1

  • 1Division of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Institute of Public Health, Florida A&M University, Tallahassee, FL 32307, USA.

Nutrients
|April 30, 2021
PubMed

Insights

Flavonoids show promise for treating triple-negative breast cancer (TNBC) by regulating microRNAs (miRNAs). These natural compounds offer a potentially low-toxicity approach to combatting TNBC progression and recurrence.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Triple-negative breast cancer (TNBC) incidence is rising, necessitating novel, low-toxicity treatment strategies.
  • Flavonoids, natural compounds with antioxidant and anti-inflammatory properties, are emerging as potential therapeutic agents.
  • MicroRNAs (miRNAs) play a critical role in TNBC development and progression.

Purpose of the Study:

  • To review the role of miRNAs in TNBC progression.
  • To explore the effects of flavonoids on miRNA regulation in TNBC.
  • To highlight the potential of flavonoids in TNBC prevention and treatment.

Main Methods:

  • Literature review of preclinical and epidemiological studies.
  • Analysis of flavonoid mechanisms in modulating miRNA expression.
  • Examination of miRNA-mediated biological processes impacted by flavonoids in TNBC.

Main Results:

  • Flavonoids can modulate miRNA levels by targeting oncogenic or oncosuppressor miRNAs.
  • Flavonoids influence key TNBC processes like cell cycle, apoptosis, proliferation, invasion, and EMT via miRNA regulation.
  • Flavonoids impact crucial biological pathways in TNBC, including immune response, inflammation, and angiogenesis, through miRNAs.

Conclusions:

  • Flavonoids demonstrate significant potential as therapeutic agents for TNBC due to their ability to regulate miRNAs.
  • Targeting miRNA pathways with flavonoids offers a promising strategy for TNBC prevention and treatment with potentially reduced toxicity.
  • Further research into flavonoid-miRNA interactions is warranted to develop effective TNBC therapies.
Keywords:
cancerflavonoidmicroRNAtriple-negative breast cancer

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