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Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
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Updated: Nov 7, 2025

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Rhinovirus and Cell Death.

Shannic-Le Kerr1, Cynthia Mathew1, Reena Ghildyal1

  • 1Faculty of Science and Technology, University of Canberra, Canberra 2617, Australia.

Viruses
|April 30, 2021
PubMed
Summary
This summary is machine-generated.

Rhinoviruses (RVs) hijack host cell death pathways like necroptosis and autophagy for replication. This review consolidates research on RVs and cell death, suggesting their role in viral release, but notes a lack of studies on RV-C strains.

Keywords:
apoptosisautophagycell death pathwayslifecyclenecroptosisnecrosisrhinovirus

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Area of Science:

  • Virology
  • Cell Biology
  • Immunology

Background:

  • Rhinoviruses (RVs) cause common colds and exacerbate asthma/COPD.
  • Viruses manipulate host cell death pathways to promote replication.
  • RVs are non-enveloped, positive-sense RNA viruses replicating in the cytoplasm.

Purpose of the Study:

  • To review and consolidate literature on RVs' impact on host cell death pathways.
  • To identify potential mechanisms of RV release from infected cells.
  • To highlight knowledge gaps, particularly concerning RV-C strains.

Main Methods:

  • Systematic literature search of peer-reviewed English language studies from the past 21 years.
  • Focus on studies investigating RV interaction with and modulation of cell death pathways.
  • Contextualization within broader knowledge of interconnected cell death pathways.

Main Results:

  • Evidence suggests a role for necroptosis and/or autophagy in RV release.
  • Rhinovirus lifecycle and replication strategies are explored in relation to cell death.
  • Current literature primarily focuses on RV-A and RV-B strains.

Conclusions:

  • Necroptosis and autophagy are strongly implicated in RV release.
  • Further research is needed to understand RV-C strain interactions with cell death pathways.
  • Understanding RV-host cell death interactions is crucial for developing antiviral strategies.