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Left Ventricular Remodeling in Hypertrophic Cardiomyopathy: An Overview of Current Knowledge

Beatrice Musumeci1, Giacomo Tini1, Domitilla Russo1

  • 1Cardiology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sapienza University of Rome, 00189 Rome, Italy.

Journal of Clinical Medicine
|April 30, 2021
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) can involve progressive left ventricular (LV) remodeling. Identifying remodeling patterns is crucial for personalized management and improved patient outcomes in HCM.

Area of Science:

  • Cardiology
  • Pathophysiology
  • Medical Imaging

Background:

  • Most hypertrophic cardiomyopathy (HCM) patients have stable disease.
  • Some HCM patients experience progressive left ventricular (LV) remodeling.
  • LV remodeling involves changes in LV wall thickness, cavity size, and function.

Purpose of the Study:

  • To define and characterize LV remodeling in HCM.
  • To explore the pathophysiologic mechanisms driving LV remodeling.
  • To investigate the clinical impact of different LV remodeling patterns.

Main Methods:

  • Serial multimodal clinical evaluations.
  • Instrumental assessments for LV morphology and function.
  • Analysis of genetic background, myocardial ischemia, and fibrosis.

Main Results:

  • Recognized distinct patterns of LV remodeling in HCM.
  • Associated specific remodeling patterns with clinical course and management.
  • Highlighted the role of genetic, ischemic, and fibrotic factors.

Conclusions:

  • Serial evaluations are essential for identifying and characterizing LV remodeling in HCM.
  • Understanding LV remodeling stages can improve HCM patient management.
  • Personalized therapeutic strategies may benefit from detailed remodeling assessment.

Keywords:
end stagehypertrophic cardiomyopathyleft ventricular remodelingrisk stratification

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