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Updated: Nov 7, 2025

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
Published on: July 29, 2014
Recent Advances in PRRS Virus Receptors and the Targeting of Receptor-Ligand for Control
Chia-Ming Su1, Raymond Robert Richard Rowland1, Dongwan Yoo1
1Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.
Abstract:
Cellular receptors play a critical role in viral infection. At least seven cellular molecules have been identified as putative viral entry mediators for porcine reproductive and respiratory syndrome virus (PRRSV). Accumulating data indicate that among these candidates, CD163, a cysteine-rich scavenger receptor on macrophages, is the major receptor for PRRSV. This review discusses the recent advances and understanding of the entry of PRRSV into cells, viral pathogenesis in CD163 gene-edited swine, and CD163 as a potential target of receptor-ligand for the control of PRRS.
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