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Fluid intake and bladder cancer in Utah
M L Slattery1, D W West, L M Robison
1Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City 84132.
International Journal of Cancer
|July 15, 1988
Summary
Fluid intake and bladder cancer risk are not linked overall. However, consuming milk may protect against bladder cancer, while high intake of coffee, alcohol, and tea may increase risk, especially in non-smokers.
Area of Science:
- Epidemiology
- Urology
- Nutritional Science
Background:
- Bladder cancer is a significant public health concern.
- The role of fluid intake in bladder cancer etiology requires further investigation.
- Previous studies have yielded inconsistent results regarding fluid consumption and bladder cancer risk.
Purpose of the Study:
- To investigate the association between total fluid intake and specific beverage consumption with bladder cancer risk.
- To explore potential dose-response relationships and effect modification by smoking status.
Main Methods:
- Population-based, incident case-control study conducted in Utah.
- Identified 419 bladder cancer cases and 889 controls.
- Utilized multiple logistic regression analysis, adjusting for smoking, age, sex, diabetes, and bladder infections.
Main Results:
- Total fluid intake was not associated with bladder cancer.
- Milk intake showed a protective effect (OR = 0.64), with a linear trend.
- High consumption of caffeinated coffee (≥40 cups/week), alcohol (>3.64 oz/week), and tea increased risk, particularly in non-smokers.
Conclusions:
- Specific beverage types, not total fluid volume, may influence bladder cancer development.
- Dietary components within beverages are hypothesized to play a role.
- Findings suggest personalized fluid consumption advice may be warranted based on beverage type and smoking status.