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Lipodystrophy as a Late Effect after Stem Cell Transplantation.

Daniel Tews¹, Ansgar Schulz², Christian Denzer¹

¹Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, 89075 Ulm, Germany.

Journal of Clinical Medicine

|April 30, 2021

Summary

Childhood cancer survivors face increased risks of adult metabolic diseases. This review highlights partial lipodystrophy after hematopoietic stem cell transplantation (HSCT), suggesting a new form of acquired lipodystrophy.

Keywords:

adipose tissue lipodystrophy stem cells

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Area of Science:

Oncology
Endocrinology
Hematology

Background:

Survivors of childhood cancer have a higher incidence of metabolic disorders in adulthood.
Partial lipodystrophy has been recently observed in patients post-hematopoietic stem cell transplantation (HSCT).

Purpose of the Study:

To review and summarize reported cases of partial lipodystrophy following HSCT.
To discuss the potential mechanisms contributing to HSCT-associated lipodystrophy.

Main Methods:

Literature review of case studies and relevant research.
Analysis of clinical data and proposed pathogenetic mechanisms.

Main Results:

Several cases of partial lipodystrophy post-HSCT have been documented.
The findings indicate a potential link between HSCT and the development of lipodystrophy.

Conclusions:

HSCT-associated lipodystrophy represents a potentially novel form of acquired lipodystrophy.
Further research is warranted to elucidate the underlying mechanisms and long-term implications.