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Modeling the Dynamics of T-Cell Development in the Thymus.

Philippe A Robert1, Heike Kunze-Schumacher2, Victor Greiff1

  • 1Department of Immunology, University of Oslo, 0372 Oslo, Norway.

Entropy (Basel, Switzerland)
|April 30, 2021
PubMed
Summary

The thymus develops T cells, crucial for adaptive immunity and self-tolerance. This review explores experimental and mathematical approaches to understand T cell development dynamics and challenges in current research.

Keywords:
T-cell developmentT-cell receptor (TCR)agent-based modelscomplex systemsmathematical modelingmulti-scale modelsordinary differential equations (ODE)thymic selection

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