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Updated: Nov 7, 2025
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
Alkyphenol Exposure Alters Steroidogenesis in Male Lizard Podarcis siculus
Mariana Di Lorenzo1, Aldo Mileo1, Vincenza Laforgia1,2
1Department of Biology, University of Naples ''Federico II'', 80126 Naples, Italy.
Background:
Nonylphenol (NP) and Octylphenol (OP) are persistent and non-biodegradable environmental contaminants classified as endocrine disruptor chemicals (EDCs). These compounds are widely used in several industrial applications and present estrogen-like properties, which have extensively been studied in aquatic organisms. The present study aimed to verify the interference of these compounds alone, and in mixture, on the reproductive cycle of the male terrestrial vertebrate Podarcis siculus, focusing mainly on the steroidogenesis process.
Methods:
Male lizards have been treated with different injections of both NP and OP alone and in mixture, and evaluation has been carried out using a histological approach.
Results:
Results obtained showed that both substances are able to alter both testis histology and localization of key steroidogenic enzymes, such as 3β-hydroxysteroid dehydrogenase (3β-HSD), 17β- hydroxysteroid dehydrogenase (17β-HSD) and P450 aromatase. Moreover, OP exerts a preponderant effect, and the P450 aromatase represents the major target of both chemicals.
Conclusions:
In conclusion, NP and OP inhibit steroidogenesis, which in turn may reduce the reproductive capacity of the specimens.
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