Related Experiment Video
Updated: Nov 7, 2025
11:06
Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells
Published on: February 24, 2014
13.2K
Inborn Errors of Immunity and Cancer
Alessandra Tiri1, Riccardo Masetti2, Francesca Conti2
1Pediatric Clinic, Pietro Barilla Children's Hospital, University of Parma, 43126 Parma, Italy.
Biology
|April 30, 2021
Summary
Inborn Errors of Immunity (IEI) increase cancer risk in children, ranging from 4-25%. Early detection and collaboration between immunologists and oncologists are crucial for managing cancer in IEI patients.
Area of Science:
- Immunology
- Oncology
- Genetics
Background:
- Inborn Errors of Immunity (IEI) are genetic disorders affecting immune system function.
- IEI patients exhibit a higher susceptibility to various health complications, including malignancies.
Purpose of the Study:
- To review the epidemiology, pathogenesis, and management of tumors in patients with Inborn Errors of Immunity.
- To highlight the increased cancer risk associated with IEI and inform clinical practice.
Main Methods:
- A narrative review of studies published in PubMed over the last 20 years.
- Keywords used: "inborn errors of immunity" or "primary immunodeficiency" and "cancer" or "tumour" or "malignancy".
Main Results:
- The overall cancer risk in children with IEI ranges from 4% to 25%.
- Factors influencing cancer development include patient age, viral infection status, and specific IEI type.
- Certain IEI types are associated with specific cancer risks.
Conclusions:
- A synergistic approach between immunologists and oncologists is vital for early cancer detection in IEI patients.
- Establishing an international registry for IEI and malignancy data is essential for improving diagnosis and treatment outcomes.
Related Concept Videos
02:59Cancer Prevention
7.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
7.2K
01:21Introduction to Innate and Adaptive Immunity
6.6K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
6.6K
01:25Immunodeficiency Diseases
1.4K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.4K
02:21Cancers Originate from Somatic Mutations in a Single Cell
13.4K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
13.4K
02:53Adaptive Mechanisms in Cancer Cells
6.1K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
6.1K
01:40Cell-mediated Immune Responses
78.9K
Overview
78.9K