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Updated: Nov 7, 2025

Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders
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Immunohistochemical Visualization of Hippocampal Neuron Activity After Spatial Learning in a Mouse Model of Neurodevelopmental Disorders

Published on: May 12, 2015

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JNK Pathway in CNS Pathologies

Teresa de Los Reyes Corrales1, María Losada-Pérez1, Sergio Casas-Tintó1

  • 1Instituto Cajal (CSIC), Av. Doctor Arce 37, 28002 Madrid, Spain.

International Journal of Molecular Sciences
|April 30, 2021
PubMed

Insights

The c-Jun N-terminal kinase (JNK) pathway is crucial for cellular stress responses and tissue homeostasis. This review highlights JNK

Area of Science:

  • Molecular Biology
  • Neuroscience
  • Cellular Biology

Background:

  • The c-Jun N-terminal kinase (JNK) signaling pathway is a fundamental cellular stress response mechanism.
  • JNK signaling is integral to tissue homeostasis, regulating apoptosis, growth, proliferation, differentiation, migration, and invasion.
  • This pathway exhibits cell-tissue specificity and plays a significant role in regeneration, tumorigenesis, and various pathologies.

Purpose of the Study:

  • To review the critical implications of the JNK pathway in central nervous system (CNS) pathologies.
  • To discuss novel mechanisms of JNK-driven tumor progression in glioblastoma.
  • To explore JNK's role in CNS injury repair, neurodegeneration, and neuronal cell death.

Main Methods:

  • Literature review of existing research on JNK signaling in the CNS.
  • Analysis of newly identified examples and mechanisms of JNK involvement in CNS diseases.
  • Synthesis of findings to support the role of JNK in CNS pathologies.

Main Results:

  • The JNK pathway is highly active in the CNS and is central to cellular responses to pathophysiological insults.
  • Specific examples of JNK-driven glioblastoma progression are detailed.
  • The review elucidates JNK's involvement in regeneration, repair, neurodegeneration, and neuronal death within the CNS.

Conclusions:

  • The JNK pathway is a key player in a variety of CNS pathologies.
  • These findings reinforce the potential of targeting the JNK pathway to mitigate detrimental effects in CNS diseases.
  • JNK signaling represents a promising therapeutic target for CNS disorders.
Keywords:
CNS injuriesMAP kinasecell signallingglioblastomaneurodegenerative disorders

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