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Updated: Nov 7, 2025
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Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
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Development of Pigmentation-Regulating Agents by Drug Repositioning
Seo-Mi-Gon Jeong1, Tae-Jin Yoon1,2
1Department of Dermatology, School of Medicine, Gyeongsang National University & Hospital, Jinju 52727, Korea.
International Journal of Molecular Sciences
|April 30, 2021
Summary
Drug repositioning identified nilotinib, sorafenib, and ICG-001 as potential pigmentation-promoting agents. 5-iodotubercidin was found to inhibit pigmentation, offering new therapeutic avenues for skin disorders.
Area of Science:
- Dermatology and pharmacology.
- Molecular biology and genetics of pigmentation.
Background:
- Skin color relies on melanin synthesis and distribution.
- Defects in melanin pathways cause pigmentation disorders.
- Drug repositioning offers novel therapeutic development strategies.
Purpose of the Study:
- To identify existing drugs that can regulate skin pigmentation.
- To explore drug repositioning for treating pigmentation disorders.
Main Methods:
- Systematic research on drugs affecting pigmentation control.
- Evaluation of drug repositioning potential for identified compounds.
Main Results:
- Nilotinib, sorafenib, and ICG-001 were identified as promoting pigmentation.
- 5-iodotubercidin was identified as inhibiting pigmentation.
Conclusions:
- Nilotinib, sorafenib, ICG-001, and 5-iodotubercidin show potential as therapeutics for pigmentation disorders.
- Drug repositioning is a viable strategy for discovering novel pigmentation treatments.
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