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Targeting CCN Proteins in Rheumatoid Arthritis and Osteoarthritis

Iona J MacDonald1, Chien-Chung Huang2,3, Shan-Chi Liu4

  • 1Graduate Institute of Basic Medical Science, Collage of Medicine, China Medical University, Taichung 40402, Taiwan.

International Journal of Molecular Sciences
|April 30, 2021
PubMed

Insights

The CCN proteins are crucial in inflammation, angiogenesis, and wound healing. This review explores their role in rheumatoid arthritis and osteoarthritis, highlighting their therapeutic potential.

Area of Science:

  • Biochemistry and Molecular Biology
  • Immunology
  • Rheumatology

Background:

  • The CCN family of matricellular proteins (CYR61/CCN1, CTGF/CCN2, NOV/CCN3, WISP1-2-3/CCN4-5-6) are key regulators of cellular processes like proliferation, adhesion, migration, differentiation, and extracellular matrix remodeling.
  • These proteins play significant roles in angiogenesis, wound healing, and inflammation.

Purpose of the Study:

  • To review the evidence implicating CCN proteins in the pathogenesis of rheumatoid arthritis (RA) and osteoarthritis (OA).
  • To explore the therapeutic potential of CCN proteins as targets for treating RA and OA.

Main Methods:

  • Literature review of existing studies on CCN proteins and their involvement in inflammatory joint diseases.
  • Analysis of evidence linking specific CCN proteins (CCN1-6) to the development and progression of RA and OA.

Main Results:

  • Strong evidence implicates CCN1, CCN2, CCN3, and CCN4 in the inflammatory pathologies of RA and OA.
  • Emerging evidence suggests a role for CCN5 and CCN6 in the development of these arthritic conditions.

Conclusions:

  • The CCN protein family is significantly involved in the pathophysiology of RA and OA.
  • CCN proteins represent promising therapeutic targets for the management of inflammatory joint diseases.
Keywords:
CCN familyCCN proteinsjuvenile idiopathic arthritisosteoarthritisrheumatoid arthritis

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