Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer Vaccines01:30

Cancer Vaccines

603
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
603
Tumor Immunotherapy01:27

Tumor Immunotherapy

807
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
807
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Vaccination with cationic liposome-encapsulated CD4 and CD8 T cell neoepitopes induces superior tumor control.

Materials today. Bio·2026
Same author

Solid-Phase Synthesis and Immunological Evaluation of Peptide Conjugates Containing Stereochemically Defined UPam-Based TLR2 Ligands and Epitopes from SARS-CoV-2 Virus.

Bioconjugate chemistry·2025
Same author

Dysfunctional CD4 T cells in an oncovirus-specific TCR-transgenic in vivo model.

Nature communications·2025
Same author

A Comprehensive Design-to-skin Pipeline to Fabricate Polymeric Microneedles Using Ultrahigh-resolution 3D Printing.

Pharmaceutical research·2025
Same author

Impact of skin model and dissolvable microneedle design on efficiency of cutaneous protein delivery.

International journal of pharmaceutics·2025
Same author

Preclinical development and clinical safety assessment of a synthetic peptide conjugate enabling endogenous antibody binding to promote innate receptor engagement.

Molecular therapy. Oncology·2025

Related Experiment Video

Updated: Nov 7, 2025

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination
11:07

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

13.4K

Cationic Nanoparticle-Based Cancer Vaccines.

Jeroen Heuts1,2, Wim Jiskoot2, Ferry Ossendorp1

  • 1Department of Immunology, Leiden University Medical Centre, 2300 RC Leiden, The Netherlands.

Pharmaceutics
|April 30, 2021
PubMed
Summary

Cationic nanoparticles effectively deliver cancer antigens to immune cells, enhancing anti-cancer immune responses. This review explores how their cationic nature boosts cancer immunotherapy efficacy.

Keywords:
cancerimmunotherapyliposomesnanoparticlespolymersvaccine

More Related Videos

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
07:33

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

2.0K
Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors
11:52

Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors

Published on: June 18, 2013

11.2K

Related Experiment Videos

Last Updated: Nov 7, 2025

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination
11:07

Whole-animal Imaging and Flow Cytometric Techniques for Analysis of Antigen-specific CD8+ T Cell Responses after Nanoparticle Vaccination

Published on: April 29, 2015

13.4K
Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo
07:33

Preparation, Characteristics, Toxicity, and Efficacy Evaluation of the Nasal Self-Assembled Nanoemulsion Tumor Vaccine In Vitro and In Vivo

Published on: September 28, 2022

2.0K
Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors
11:52

Analysis of Targeted Viral Protein Nanoparticles Delivered to HER2+ Tumors

Published on: June 18, 2013

11.2K

Area of Science:

  • Nanomedicine
  • Immunology
  • Oncology

Background:

  • Cationic nanoparticles are effective cancer vaccine vehicles in preclinical and clinical studies.
  • They deliver tumor-associated antigens to dendritic cells, activating immune responses.
  • This leads to strong antigen-specific cellular immunity for various vaccine candidates.

Purpose of the Study:

  • To review the relationship between nanoparticle cationic properties and cancer immunotherapy efficacy.
  • To describe various cationic nanoparticulate cancer vaccines and their antigen types.
  • To focus on cationic nanoparticles for T-cell induction in therapeutic cancer vaccination.

Main Methods:

  • Review of lipid- and polymer-based cationic nanoparticulate cancer vaccines.
  • Analysis of different antigen types (mRNA, DNA, peptides, proteins) and adjuvants.
  • Discussion of molecular mechanisms of adjuvanticity and biodistribution profiles.

Main Results:

  • Cationic nanoparticles enhance antigen presentation and immune activation.
  • Various cationic nanoparticulate vaccines demonstrate efficacy in preclinical and clinical settings.
  • Specific nanoparticle types are crucial for effective T-cell induction.

Conclusions:

  • The cationic nature of nanoparticles is key to their efficacy in cancer immunotherapy.
  • Cationic nanoparticulate vaccines hold significant promise for improving cancer treatment.
  • Further research into mechanisms and delivery routes will optimize their application.