Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Molecular Chaperones and Protein Folding03:00

Molecular Chaperones and Protein Folding

18.9K
The native conformation of a protein is formed by interactions between the side chains of its constituent amino acids. When the amino acids cannot form these interactions, the protein cannot fold by itself and needs chaperones. Notably, chaperones do not relay any additional information required for the folding of polypeptides; the native conformation of a protein is determined solely by its amino acid sequence. Chaperones catalyze protein folding without being a part of the folded protein.
The...
18.9K
Molecular Chaperones and Protein Folding03:00

Molecular Chaperones and Protein Folding

14.1K
14.1K
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

6.1K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
6.1K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

4.0K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
4.0K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.0K
Bacterial Protein Maturation01:26

Bacterial Protein Maturation

190
Bacterial protein maturation is a tightly regulated process that ensures newly synthesized polypeptides achieve correct functional conformations. This maturation involves a series of modifications, folding events, and quality control steps, often assisted by specialized chaperone proteins.N-Terminal ModificationsThe maturation of bacterial polypeptides begins cotranslationally as the polypeptide exits the ribosome. The first amino acid, N-formylmethionine (fMet), is typically modified at the...
190

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Real-World Study on the Effectiveness and Safety of Elacestrant in Patients with <i>ESR1</i>-Mutated Metastatic Breast Cancer Progressing After CDK4/6 Inhibitors and Endocrine Therapy.

Cancers·2026
Same author

Decoding Glioblastoma Complexity Through Extracellular Vesicles, Organ-on-Chip Models, and Deep Learning.

Cells·2026
Same author

Extracellular Vesicle-Mediated Communication in Sellar Tumors: A Conceptual and Translational Framework.

International journal of molecular sciences·2026
Same author

Cellular Stress and Immune Activation in Celiac Disease: Is the Chaperone System a Key Player?

Biology·2026
Same author

The Muco-Microbiotic Layer in Respiratory Pathophysiology: Integrating Transcriptomics, Inflammation Phenotypes, and Clinical Biomarkers in Precision Pulmonology.

Biology·2026
Same author

Standardized Workflow for the Generation of Patient-Derived Glioblastoma Spheroids.

Methods and protocols·2026

Related Experiment Video

Updated: Nov 7, 2025

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
07:02

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

7.6K

Molecular Chaperones and Thyroid Cancer.

Letizia Paladino1,2, Alessandra Maria Vitale1,2, Radha Santonocito1

  • 1Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), Institute of Human Anatomy and Histology, University of Palermo, 90127 Palermo, Italy.

International Journal of Molecular Sciences
|April 30, 2021
PubMed
Summary

Chaperone proteins are altered in thyroid cancers, aiding tumor growth. Understanding these changes could lead to new diagnostic tools and targeted therapies for endocrine malignancies.

Keywords:
Hsp27Hsp60Hsp70Hsp90chaperone systemchaperonopathies by mistakechaperonotherapydifferential diagnosismolecular chaperonesthyroid tumors

More Related Videos

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.9K
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

21.3K

Related Experiment Videos

Last Updated: Nov 7, 2025

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
07:02

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

7.6K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

1.9K
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
07:01

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

Published on: April 17, 2013

21.3K

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Thyroid cancers are common endocrine malignancies requiring improved diagnosis and treatment.
  • The chaperone system (CS) plays a role in cancer development, with altered CS component levels correlating with tumor characteristics.

Purpose of the Study:

  • To review studies on chaperone system components in various thyroid cancers.
  • To explore the diagnostic and therapeutic potential of chaperone alterations in thyroid tumorigenesis.

Main Methods:

  • Immunohistochemistry and Western blot were used to quantify chaperone proteins.
  • Analysis was performed on tumor tissues, normal tissues, and extracellular vesicles.

Main Results:

  • Distinctive quantitative differences in chaperone proteins (Hsp70, Hsp90, Hsp60) were observed across different thyroid tumor types.
  • Most frequently, chaperone levels were increased in tumors, linked to accelerated cancer cell metabolism and proliferation.

Conclusions:

  • Chaperone system alterations are significant in thyroid cancer, potentially serving as biomarkers for differential diagnosis and prognosis.
  • Targeting pathogenic chaperones (chaperonotherapy) presents a promising therapeutic strategy for thyroid malignancies.