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Biosensing Near the Exceptional Point Based on Resonant Optical Tunneling Effect
Yang Liu1,2, Pengyun Yan1,2, Feng Liu1,2
1MicroNano System Research Center, Taiyuan University of Technology, Taiyuan 030024, China.
Micromachines
|April 30, 2021
Summary
This study introduces a novel biosensor using exceptional point (EP) sensing for highly sensitive, label-free detection of low-concentration analytes. Convection loading enhances efficiency and response time for biomedical and environmental applications.
Area of Science:
- Non-Hermitian physics
- Optical sensing
- Biosensor technology
Background:
- Exceptional points (EPs) in non-Hermitian systems offer unique sensing capabilities.
- Label-free detection is crucial for real-time monitoring of analytes.
- Existing biosensors face challenges with sensitivity and response time.
Purpose of the Study:
- To propose a novel label-free biosensor for detecting low-concentration analytes.
- To leverage exceptional point (EP) sensing in a resonant optical tunneling resonator.
- To enhance analyte capture efficiency and reduce sensor response time.
Main Methods:
- Utilizing a special multilayer resonant optical tunneling resonator structure.
- Analyzing sensor performance with coupled-mode theory and transfer matrix method.
- Employing convection loading for liquid sample delivery.
Main Results:
- Achieved a sensitivity of 17,120 nm/imaginary part unit of refractive index (IP).
- Demonstrated a theoretical detection limit of 4.2 × 10-8 IP.
- Simulated a minimum detection value of 1.78 ng for carcinoembryonic antigen (CEA).
Conclusions:
- The proposed biosensor effectively detects low-concentration analytes with high sensitivity.
- Convection loading significantly improves sample capture and reduces response time.
- Potential applications include biomedical detection, environmental monitoring, and water safety analysis.
