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Detection of SARS-COV-2 Proteins Using an ELISA Test
Marina Di Domenico1,2, Alfredo De Rosa3, Mariarosaria Boccellino1
1Department of Precision Medicine, University of Campania "Luigi Vanvitelli", 81100 Naples, Italy.
Diagnostics (Basel, Switzerland)
|April 30, 2021
Summary
This study developed a rapid, sensitive, and specific diagnostic device for SARS-CoV-2 infection. The patient-side test identifies viral antigens, aiding in early COVID-19 detection and transmission control.
Area of Science:
- Medical diagnostics
- Virology
- Public health
Background:
- The COVID-19 pandemic highlighted the need for rapid diagnostic tools.
- Current RT-PCR tests, while reliable, require laboratory processing.
- Timely identification of SARS-CoV-2 infection is crucial for disease control.
Purpose of the Study:
- To develop a qualitative, rapid, sensitive, and specific diagnostic method for SARS-CoV-2.
- To create a point-of-care device for detecting specific SARS-CoV-2 viral antigens.
- To enable immediate diagnosis outside traditional laboratory settings.
Main Methods:
- Assembly of a diagnostic device using commercial and custom components.
- Application of a method for recognizing specific SARS-CoV-2 antigens.
- Testing performed at the patient's side with a chemocolorimetric or digital reader (ELISA).
Main Results:
- The developed method provides a rapid and specific diagnosis of SARS-CoV-2 infection.
- The device allows for testing outside the laboratory environment.
- Results are available immediately via a colorimetric response or digital reader.
Conclusions:
- A novel, rapid, and sensitive diagnostic approach for SARS-CoV-2 infection has been established.
- The patient-side device offers a viable alternative for quick COVID-19 diagnosis.
- This technology can significantly contribute to controlling the spread of SARS-CoV-2.
