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Theranostics in Boron Neutron Capture Therapy.

Wolfgang A G Sauerwein1,2,3, Lucie Sancey4, Evamarie Hey-Hawkins1,5

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Summary

Boron neutron capture therapy (BNCT) offers targeted tumor destruction. Combining boron delivery with imaging could enable non-invasive 10B measurement for precise BNCT optimization.

Keywords:
BNCTBPABSHPETcell-penetrating peptides CPPimage registrationproteomicsquantitative MRIradiation oncologysmall molecules

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Boron neutron capture therapy (BNCT) is a binary treatment utilizing 10B and thermal neutrons for tumor cell destruction.
  • Current BNCT efficacy is limited by the inability to non-invasively measure 10B concentration within specific tissues.
  • Estimating tissue boron concentration relies on imprecise assumptions about blood-to-tissue uptake.

Purpose of the Study:

  • To review innovative drug development for boron delivery systems in BNCT.
  • To explore the integration of concurrent imaging with boron delivery agents.
  • To highlight the role of proteomics in advancing BNCT precision and personalization.

Main Methods:

  • Review of current clinical protocols and preclinical experiments in BNCT.
  • Analysis of novel boron delivery systems incorporating imaging capabilities.
  • Examination of proteomics applications for BNCT optimization.

Main Results:

  • Development of boron delivery systems that integrate imaging offers a path to non-invasive 10B quantification in tumors.
  • Concurrent imaging can improve the precision of BNCT by allowing real-time assessment of boron distribution.
  • Proteomics provides insights into cellular mechanisms that can be leveraged to enhance boron uptake and therapeutic outcomes.

Conclusions:

  • Integrating imaging with boron delivery agents is crucial for advancing BNCT.
  • Non-invasive 10B measurement will enable more accurate treatment planning and personalized therapy.
  • Proteomics holds significant potential for optimizing BNCT, making it a more precise and personalized therapeutic option.