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Plasmonic Biosensors for Single-Molecule Biomedical Analysis.

Elba Mauriz1,2, Laura M Lechuga3

  • 1Department of Nursing and Physiotherapy, Universidad de León, Campus de Vegazana, s/n, 24071 León, Spain.

Biosensors
|April 30, 2021
PubMed
Summary
This summary is machine-generated.

Plasmonic biosensing enables ultrasensitive detection of single molecules for diagnosing diseases like COVID-19. This review highlights advances in plasmonic technologies for monitoring biomarkers and advancing personalized medicine.

Keywords:
biosensorsliving-cellsnanoparticlenanostructurenucleic acidsplasmonicssingle-molecule analysisvirus

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Area of Science:

  • Nanotechnology
  • Biomedical Engineering
  • Analytical Chemistry

Background:

  • The global rise of epidemic diseases, such as coronavirus disease 2019 (COVID-19), necessitates ultrasensitive diagnostic methods.
  • Single-molecule analytical platforms are crucial for advancing medical diagnostics and understanding biological interactions.
  • Plasmonic biosensing has emerged as a powerful technique for detecting individual molecules with high sensitivity.

Purpose of the Study:

  • To review the latest advancements in plasmonic technologies for single-molecule analysis.
  • To discuss functional applications of plasmonic biosensing for monitoring clinically relevant biomarkers.
  • To explore the potential of plasmonic-based single-molecule analysis in personalized medicine.

Main Methods:

  • Review of recent literature on plasmonic biosensing technologies.
  • Categorization of plasmonic sensing modes (nanoapertures and nanoparticles).
  • Analysis of applications for various analytes including proteins, cells, nucleic acids, and viruses.

Main Results:

  • Plasmonic biosensing enables the detection and characterization of individual molecules.
  • Diverse plasmonic sensing strategies have been developed for a wide range of analytes.
  • Progress has been made in applying these technologies to monitor biomarkers and biological interactions.

Conclusions:

  • Plasmonic biosensing offers significant potential for ultrasensitive biomarker detection at the single-molecule level.
  • These technologies are advancing the field of personalized medicine by enabling detailed molecular analysis.
  • Further development is needed to overcome technological limitations and fully realize the clinical utility of plasmonic single-molecule analysis.