Plant-Based Indole Alkaloids: A Comprehensive Overview from a Pharmacological Perspective
Faisal Omar1, Abu Montakim Tareq1, Ali M Alqahtani2
1Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh.
Molecules (Basel, Switzerland)
|April 30, 2021
Summary
Plant-derived indole alkaloids exhibit diverse pharmacological activities, with potential for new drug discovery. This review highlights 100 compounds and their promising therapeutic applications.
Area of Science:
- Natural Products Chemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Indole alkaloids from plants are recognized for significant pharmacological properties.
- The indole nucleus is a key structural feature contributing to these activities.
Purpose of the Study:
- To review and evaluate the pharmacological potential of plant-derived indole alkaloids.
- To identify potential new lead compounds for drug development.
Main Methods:
- Comprehensive literature search across major scientific databases and online books.
- Identification and review of 100 plant-based indole compounds.
- Evaluation of reported pharmacological activities and pharmacokinetic profiles.
Main Results:
- 100 indole compounds were reviewed, exhibiting a wide spectrum of activities.
- Key activities include anticancer, antimicrobial, anti-inflammatory, and CNS-related effects.
- Pharmacokinetic data for selected compounds like mitragynine and vindoline were assessed.
Conclusions:
- Plant-derived indole alkaloids demonstrate broad and promising pharmacological activities.
- Further in-depth evaluation is warranted to explore their potential as novel therapeutic agents.
- This review provides a foundation for identifying new drug leads from natural sources.
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